PRP vs. Cortisone
15 Sep

PRP vs. Cortisone for Knee Pain – Which One Is Right for You?

When dealing with chronic knee pain, two common treatments come up: PRP and cortisone. But how do they differ—and which one might be the better choice for your situation?


What’s the Difference?

FactorPRPCortisone
SourceCommercial biologicSynthetic steroid
GoalStimulate healingReduce inflammation
OnsetSlower (1–4 weeks)Fast (1–3 days)
DurationMonths or moreWeeks to months
RiskLowCartilage weakening with repeated use
InsuranceOut-of-pocket at Dr. Burke’sUsually covered

When to Consider PRP

PRP may be right if:

  • You have early arthritis or tendon injury
  • You’ve had limited success with other injections
  • You’re trying to avoid long-term steroid use
  • You’re seeking a biological solution

When to Consider Cortisone

Cortisone may help if:

  • You’re in a pain flare-up and need quick relief
  • You’ve never had an injection before
  • You want to try the most conservative option first

Dr. Burke’s Perspective

Dr. Burke helps each patient evaluate:

  • Imaging results
  • Pain severity
  • Previous treatments
  • Lifestyle goals

At his practice, PRP is offered as a cash-pay treatment after a full evaluation confirms it’s appropriate.


Cortisone may provide fast, temporary relief. PRP may offer longer-term joint health support. The right choice depends on your body and goals—Dr. Burke can help you decide.

Ready to Find Relief from Knee Pain?

Whether you’re considering PRP, cortisone injections, or exploring other treatment options, the next step is a personalized consultation.

📞 Call us today at (713) 436-3488 or
👉 Request an Appointment Online

Our team at Dr. Burke Orthopedics is here to help you move with confidence again.