Understanding Chronic Knee Pain and Injection Options – PRP vs. Cortisone

Chronic knee pain can affect everything from walking and climbing stairs to simply getting through the day. When conservative measures like rest and therapy no longer bring relief, many patients begin exploring injection-based treatments to reduce pain and restore mobility.

Two of the most common options are PRP (Platelet-Rich Plasma) Therapy and cortisone injections. Both are widely used in orthopedic care, but they work in very different ways.

Why the Right Injection Matters

Knee pain can stem from multiple underlying issues such as osteoarthritis, tendon injuries, cartilage wear, or inflammation in the joint.
The right treatment depends on the cause of the pain, the stage of damage, and how your body responds to certain therapies.

That’s why it’s important to understand the difference between PRP and cortisone before deciding which approach aligns with your long-term goals.

PRP vs. Cortisone – Key Differences

When to Consider PRP

PRP, also known as a regenerative orthopedic treatment, may be appropriate if:

• You have early arthritis or a tendon injury
• Other injection treatments haven’t provided long-term relief
• You’re looking to avoid repeated steroid use
• You prefer a more biological and restorative approach to care

PRP works by concentrating your body’s natural growth factors to promote a healing environment inside the joint. This process takes time but may support longer-term improvement in joint comfort and function.

When to Consider Cortisone

Cortisone injections are a trusted option for short-term pain relief and inflammation control. They may be ideal if:

• You’re in a pain flare-up and need immediate comfort
• You’ve never had an injection before
• You want to try the most conservative option first

Cortisone is often used to calm inflammation and can provide relief within a few days, though the effects typically fade after several weeks or months.

Dr. Burke’s Perspective

At Dr. Burke Orthopedics, treatment decisions are based on a careful review of:

• Imaging and diagnostic results
• The severity and cause of pain
• Previous response to injections or therapy
• Your lifestyle and activity goals

After a full evaluation, Dr. Burke will discuss whether PRP or cortisone—or another approach such as viscoelastic injection therapy or physical therapy—best fits your needs.

PRP is offered as a cash-pay treatment when appropriate, following medical assessment. Cortisone may be recommended for faster, temporary relief when inflammation is the main concern.

Finding Balance Between Fast Relief and Lasting Results

Cortisone injections can help manage pain quickly, while PRP therapy may promote gradual improvement and longer-term joint health. The best choice depends on your individual condition, expectations, and timeline for recovery.

If you’re unsure which path to take, an orthopedic consultation can help clarify your options and set realistic goals for healing.

Take the Next Step Toward Relief

Whether you’re considering PRP, cortisone injections, or exploring other orthopedic treatments, a personalized care plan can help you make the right decision for your knee health.

📞 Call Dr. Burke Orthopedics at (713) 436-3488
👉 Request an Appointment Online

Serving Houston, Pearland, Friendswood, and Southeast Texas, Dr. Burke and his team are dedicated to helping patients move comfortably and confidently again.

Disclaimer:
All references to regenerative or biologic therapies on this website are for educational purposes only. Dr. Burke Orthopedics provides regenerative orthopedic care performed under FDA-cleared standards and does not advertise or sell biologic or prescription drug products.